Soutenance de Thèse de Doctorat en “ Materials Physics and Photonics ” par Mme. El Garrab CHAIMAE

The Euromed University of Fes (UEMF) is pleased to inform the public of the Doctoral Thesis Defense in “Materials Physics and Photonics” by Ms. El Garrab CHAIMAE.

The thesis defense will take place on June 23, 2026 at 02:30 PM at UEMF.

• Presented by: Ms. El Garrab CHAIMAE
• Location: The Great Hall of the Incubator (LOC001994)
• Topic: Design and Numerical Analysis of Localized Surface Plasmon Resonance-Based Biosensors for Breast Cancer Biomarker Sensing

Summary

Breast cancer remains one of the most serious global health challenges, highlighting the urgent need for sensitive and reliable tools for early detection and treatment-benefit assessment. Localized Surface Plasmon Resonance (LSPR) has demonstrated strong potential for detecting breast cancer biomarkers in recent years, thereby playing a significant role in addressing this challenge.

This thesis has primarily focused on the development of novel configurations designed to enhance the performance metrics of LSPR biosensors. First, using the Finite-Difference Time-Domain (FDTD) method, several configurations based on homo-dimers (sphere-sphere) and hetero-dimers (sphere-cube and sphere-cylinder) were proposed and investigated.

The second and third approaches explored dimers composed of core-shell nanoparticles, enabling strong plasmonic coupling and intense localized electromagnetic fields in the interparticle gap. This optimization enabled the biosensor to achieve a detection limit below the clinical diagnostic threshold of the target biomarker, thereby improving its sensitivity.

Secondly, the work was extended to an experimental study in which a novel self-referencing sensing approach was proposed to enhance measurement reliability. Two types of nanoparticles, single silver nanoparticles and silver@ZnO core-shell structures, were synthesized. The characterization of their mixture demonstrated that this methodology is highly promising for self-referenced sensing.

These findings pave the way for the optimal use of LSPR-based biosensing in the detection of breast cancer biomarkers.

This thesis will be presented to the jury members

Full Name	Grade	Institution	Quality
Pr. BELKHEIR Hammouti	PES	Euromed University of Fes	Jury Chair
Pr. KATIR Nadia	PES	Euromed University of Fes	Reviewer
Pr. SALI Ahmed	PES	USMBA, Fes	Reviewer
Pr. LIMAME Karoum	PES	CRMEF, Fes	Reviewer
Pr. SALGHI Rachid	PES	Euromed University of Fes	Examiner
Pr. AZZAOUI Khalil	PH	USMBA, Fes	Examiner
Pr. ZEKRITI Mohssin	PH	Euromed University of Fes	Thesis Director