Doctoral Thesis Defense in “Organic and Medicinal Chemistry” by Mr. Garba SULEIMAN

The Euromed University of Fes (UEMF) is pleased to inform the public of the Doctoral Thesis Defense in “Organic and Medicinal Chemistry” by Mr. Garba SULEIMAN.

The thesis defense will take place on 1st July, 2026 at 10:00 a.m. at UEMF.

• Presented by: Mr. Garba SULEIMAN
• Location: The Great Hall of the Incubator (LOC001994)
• Topic: Design, synthesis and biological activity evaluation of novel analogs of enoxacin, ciprofloxacin and ethacrynic acid

Summary

The growing challenges of cancer and antimicrobial resistance necessitate the development of new therapeutic agents. This thesis focuses on the design, synthesis, characterization, and biological evaluation of novel ethacrynic acid and fluoroquinolone derivatives with potential anticancer and antibacterial properties.

A series of structurally diverse compounds were synthesized and characterized using FTIR, NMR (1H and 13C), and HRMS techniques to confirm their structures and purity. Their biological activities were assessed through in vitro anticancer and antibacterial studies, including cytotoxicity assays, disk diffusion tests, and MIC/MBC determinations.

Several synthesized derivatives exhibited promising anticancer and antibacterial activities, highlighting the potential of both ethacrynic acid and fluoroquinolone scaffolds as valuable platforms for drug development.

To further understand their biological behavior, molecular docking, molecular dynamics simulations, ADMET prediction, and drug-likeness profiling were performed. These computational studies provided insights into ligand–target interactions, binding stability, and pharmacokinetic properties, supporting the experimental findings.

Overall, this work demonstrates that strategic structural modification of ethacrynic acid and fluoroquinolone frameworks can lead to promising bioactive compounds and provides a foundation for the future development of novel therapeutic agents.

This thesis will be presented to the jury members

Full Name	Grade	Institution	Quality
Prof. Chakib NEJJARI	Full Professor	Euromed University of Fes, Morocco	Jury Chair
Prof. El Mestafa EL HADRAMI	Full Professor	University Sidi Mohamed Ben Abdellah, Fes, Morocco	Reviewer
Prof. Youssef RAMLI	Full Professor	University Mohammed V, Rabat, Morocco	Reviewer
Prof. Abdelkrim EL KADIB	Full Professor	Euromed University of Fes, Morocco	Reviewer
Prof. Abdellatif TIKAD	Full Professor	University Moulay Ismail, Meknes, Morocco	Examiner
Prof. Edouard BADARAU	Full Professor	University of Bordeaux, France	Examiner
Prof. Nabil EL BRAHMI	Full Professor	Euromed University of Fes, Morocco	Thesis Co-Director
Prof. Saïd EL KAZZOULI	Full Professor	Euromed University of Fes, Morocco	Thesis Director