Conférence autour de la chimie par Dr. Marie-Aude Hiebel

Dr. Marie-Aude Hiebel delivered a lecture at the Euromed University of Fes, on the topic: "Hypervalent Iodine (III) in the Direct Intramolecular Formation of N-N Bonds with Heteroaromatic Amines: Synthesis of Triazapentalene Derivatives".

Abstract

The formation of N-N bonds can offer an original approach to various nitrogen-containing heterocycles, which have numerous applications. To this end, we have observed that readily available heteroaromatic amines are suitable substrates for providing an effective and innovative approach to N-N bond formation in the presence of iodine (III) reagents under very mild conditions. This method allows for the synthesis of nitrogen-rich triazapentalene derivatives that exhibit fluorescent properties, which are inaccessible using existing approaches.

Biography of Dr. Marie-Aude Hiebel

Marie-Aude Hiebel studied chemistry at the École Supérieure de Chimie de Lyon (CPE Lyon) and then obtained a master's degree (2005) and a PhD (2008) in organic chemistry from Claude Bernard Lyon 1 University, under the supervision of Prof. O. Piva. She developed various stereocontrolled accesses to 2,6-disubstituted tetrahydropyrans, which were applied to the total synthesis of diospongin A and bistramide A. During a postdoctoral stay in Prof. Molander's laboratory (UPenn, Philadelphia), she first synthesized an advanced intermediate of nakadomarin A and then carried out a methodological project around the chemistry of N-methylated trifluoroborates (synthesis and study in the Suzuki-Miyaura coupling reaction). In 2010, she joined the group of Prof. S. Routier (ICOA, Orleans), where she synthesized polyazotated heterocyclic compounds before being hired as a senior lecturer at the University of Orleans. She joined the CHeMBioLITE group (Prof. F. Suzenet and Prof. Em. G. Guillaumet) and works on the development of original organic fluorophores. She is the co-author of 30 publications and 2 book chapters and has an h-index of 14 (Web Of Science Core Collection).