Doctoral Thesis Defense in “Organic and Medicinal Chemistry” by Mr. Garba SULEIMAN

The Euromed University of Fes (UEMF) is pleased to inform the public of the Doctoral Thesis Defense in “Organic and Medicinal Chemistry” by Mr. Garba SULEIMAN.

The thesis defense will take place on 1st July, 2026 at 10:00 a.m. at UEMF.

• Presented by: Mr. Garba SULEIMAN
• Location: The Great Hall of the Incubator (LOC001994)
• Topic: Design, synthesis and biological activity evaluation of novel analogs of enoxacin, ciprofloxacin and ethacrynic acid

Summary

The growing challenges of cancer and antimicrobial resistance necessitate the development of new therapeutic agents. This thesis focuses on the design, synthesis, characterization, and biological evaluation of novel ethacrynic acid and fluoroquinolone derivatives with potential anticancer and antibacterial properties.

A series of structurally diverse compounds were synthesized and characterized using FTIR, NMR (1H and 13C), and HRMS techniques to confirm their structures and purity. Their biological activities were assessed through in vitro anticancer and antibacterial studies, including cytotoxicity assays, disk diffusion tests, and MIC/MBC determinations.

Several synthesized derivatives exhibited promising anticancer and antibacterial activities, highlighting the potential of both ethacrynic acid and fluoroquinolone scaffolds as valuable platforms for drug development.

To further understand their biological behavior, molecular docking, molecular dynamics simulations, ADMET prediction, and drug-likeness profiling were performed. These computational studies provided insights into ligand–target interactions, binding stability, and pharmacokinetic properties, supporting the experimental findings.

Overall, this work demonstrates that strategic structural modification of ethacrynic acid and fluoroquinolone frameworks can lead to promising bioactive compounds and provides a foundation for the future development of novel therapeutic agents.

This thesis will be presented to the jury members

  Prof. Chakib NEJJARI
  Full Professor
  Euromed University of Fes, Morocco
  Jury Chair



  Prof. El Mestafa EL HADRAMI
  Full Professor
  University Sidi Mohamed Ben Abdellah, Fes, Morocco
  Reviewer



  Prof. Youssef RAMLI
  Full Professor
  University Mohammed V, Rabat, Morocco
  Reviewer



  Prof. Abdelkrim EL KADIB
  Full Professor
  Euromed University of Fes, Morocco
  Reviewer



  Prof. Abdellatif TIKAD
  Full Professor
  University Moulay Ismail, Meknes, Morocco
  Examiner



  Prof. Edouard BADARAU
  Full Professor
  University of Bordeaux, France
  Examiner



  Prof. Nabil EL BRAHMI
  Full Professor
  Euromed University of Fes, Morocco
  Thesis Co-Director



  Prof. Saïd EL KAZZOULI
  Full Professor
  Euromed University of Fes, Morocco
  Thesis Director