EL KAZZOULI Said

EL KAZZOULI Saïd

BiomedTech engineering school

s.elkazzouli@ueuromed.org

2004 : Ph.D. in Organic Chemistry: University of Orléans, Institute of Organic and Analytical Chemistry, Orléans, France. Supervisor: Professor Gérald Guillaumet, President of University of Orléans in collaboration with Professor Abderrahim Mouaddib University of Cadi Ayyad. Dissertation Title: "Solid support synthesis of various heterocycles from a common synthon. Development and pharmacological evaluation of imidazo[1,2- a ]pyridine derivatives as melatonin analogues", Expertise: multi-step synthesis, imidazo[1,2- a ] pyridines, melatonin analogues, palladium and copper–catalyzed reactions, solid support synthesis, microwave synthesis.

 

2000 : MS in Organic Chemistry: Universities of Orléans, Paris V and Paris XI: Thesis Title: "Support solid synthesis of large C-terminal peptide aldehyde: application to chemoselective ligation". Expertise: solid phase synthesis, peptide chemistry. National Center for Scientific Research (CNRS), Center for Molecular Biophysics, Orléans, France. Supervisor: Agnès Delmas, Ph.D.

 

1997 : BS in Chemistry, Faculty of Sciences and Technology (FST), Beni-Mellal, Morocco.

 

  • Medicinal chemistry.

 

  • Synthesis methodologies.

 

  • Green chemistry.

 

  • Macromolecules for the vectorization of active ingredients (dendrimers).

2013-Present : Euro-Mediterranean University of Fes (UEMF), Morocco. Design and synthesis of bioactive molecules, drugs delivery by macromolecules, environmental chemistry, green chemistry, phosphate forth flotation and catalysis.

2009-2013 :  Institute of Nanomaterials and Nanotechnology, Moroccan Foundation for Advanced Sciences, Innovations and Research (MAScIR), Rabat, Morocco. Design and synthesis of bioactive molecules, drugs delivery by dendrimers, phosphate forth flotation, homogenous catalysis.

2006-2009 :  National Institutes of Health (NIH), National Cancer Institute (NCI), Frederick, Maryland, Center for Cancer Research, Laboratory of Medicinal Chemistry, USA. 

Postdoctoral Fellow (IRTA Fellow): Rational drug design and multi-step synthesis of antitumor agents, purification and characterization of biologically active diacylglycerol-lactones (DAG-lactones). Expertise: solid phase synthesis, parallel synthesis, combinatorial chemistry, diacylglycerol-lactones (DAG-lactones), protein kinase C (PKC), C1-domains.

2004-2006 : University of Orléans, Institute of Organic and Analytical Chemistry, Orléans, France.

2005-2006 : Postdoctoral Fellow in Heterocyclic Chemistry: Synthesis of herbicide, Expertise: indole chemistry, anionic reactions, in collaboration with Syngenta, Basel, Switzerland.

2005 : Postdoctoral Fellow in Nucleosides Chemistry: Synthesis of new antiviral drugs, Expertise: nucleosides chemistry, palladium–catalyzed reactions, solid support synthesis, microwave synthesis. France

2004 :  Postdoctoral Fellow in Heterocyclic Chemistry: Synthesis of new pyrimido[4,5-b][1,4]oxazines, Expertise: pyrimido[4,5-b][1,4]oxazines, palladium-catalyzed N-arylation, microwave synthesis . France

 

  1. Design, synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents, El Abbouchi, A.; El Brahmi, N.; Hiebel, MA.; Bignon, J.; Guillaumet, G.; Suzenet, F.; El Kazzouli, S. Bioorg. Med. Chem. Lett. 2020 , Accepted. (IF = 2.42) .
  2. Palladium-catalyzed oxidative arylation of 1 H -indazoles with arenes. Gambouz, K.; El Abbouchi, A.; Nassiri, S., Bousmina, M.; Akssira, M.; Guillaumet, G.; El Kazzouli, S. Eur. J.Org. Chem . 2020 , Accepted. (IF = 3.03) .
  3. “On Water” Palladium Catalyzed Direct Arylation of 1 H- Indazole and 1 H -7-Azaindazole, Gambouz, K.; El Abbouchi, A.; Nassiri, S., Bousmina, M.; Akssira, M.; Guillaumet, G.; El Kazzouli, S. Molecules. 2020 , 25, 1645. (IF = 3.06) .
  4. Direct arylation and Suzuki-Miyaura coupling of imidazo[1,2-a]pyridines catalyzed by (SIPr)Pd(allyl)Cl complex under microwave-irradiation. El Abbouchi, A.; Koubachi, J.; El Brahmi, N.; El Kazzouli . S. Med J. Chem. 2019 , 9, 347. (IF = 0.85) .
  5. Unusual rearrangement of imidazo[1,5- a ]imidazoles and imidazo[1,2- b ]pyrazoles into imidazo[1,5- a ]pyrimidines and pyrazolo[1,5- a ]pyrimidines, Gambouz, K.; Loubidi, M.; Tber, Z.; Driowy, M.; Allouchi, H.; El Kazzouli, S. Akssira, M.; Guillaumet, G. RSC Advances , 2019 , 9, 29051. (IF = 3.05) .
  6. Oxidative alkenylation of fused bicyclic heterocycles. Koubachi, J.; El Brahmi, N.; Guillaumet, G.; El Kazzouli, S. Eur. J.Org. Chem . 2019 , 2568. (IF = 3.03) .
  7. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1). Mignani, S.; Rodrigues, J.; Roy, R.; Shi, X.; Cenã, V.; El Kazzouli, S .; Majoral. JP. Drug Discov. Today , 2019 , 24, 1176. (IF = 6.88) .
  8. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 2). Mignani, S.; Rodrigues, J.; Roy, R.; Shi, X.; Cenã, V.; El Kazzouli, S .; Majoral. JP. Drug Discov. Today , 2019 , 24, 1184. (IF = 6.88) .
  9. Palladium-catalyzed C3 arylations of 1H and 2H pyrazolo[4,3-b]pyridines on water: One pot direct C3-arylations of 1 H and 2 H series. Faarasse, S.; El Kazzouli, S .; Suzenet, F.; Guillaumet, G., J. Org. Chem . 2018 , 83, 12847-12854 (IF = 4.80) .
  10. Synthesis and characterization of new organophilic clay. Preparation of polystyrene/clay nanocomposite, Ben-Yahia, A.; El Kazzouli, S.; Essassi, EM; Bousmina, MM Scientific Study and Research: Chemistry and Chemical Engineering, Biotechnology, Food Industry, 2018 , 19, 193. (IF = 0.23)
  11. “On water” direct C-3 arylation of 2H-pyrazolo[3,4-b]pyridines, Faarasse, S. El Kazzouli, S .; Naas, M.; Jouha, J.; Suzenet, F.; Guillaumet, G., J. Org. Chem . 2017 , 82 , 12300. (IF = 4.80)
  12. Original Multivalent Gold(III) and Dual Gold(III)–Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumor and Antimicrobial Agents, Mignani, S.; El Brahmi, N.; El Kazzouli, S.; Laurent, R.; Ladeira, S.; Caminade, AM.; Pedziwiatr-Werbicka, E.; Szewczyk, EM; Bryszewska, M.; Bousmina, M.; Cresteil, T.; Majoral, JP. Molecular Pharmaceutics . 2017 , 14, 4087. (IF = 4.40)
  13. Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators . Mignani, S. El Brahmi, N.; Eloy, L.; Poupon, J.; Nicolas, V.; Steinmetz, A.; El Kazzouli, S .; Bousmina, M.; Blanchard-Desce, M.; Caminade, AM.; Majoral, JP.; Cresteil, T. Eur. J.Med. Chem . 2017 , 132, 142. (IF = 4.83)
  14. Symmetrical and unsymmetrical incorporation of active biological monomers on the surface of phosphorus dendrimers . El Brahmi, N.; El Kazzouli, S .; Mignani, S.; Lawrence. R.; Ladeira. S.; Caminade, AM.; Bousmina, M.; Majoral, JP. Tetrahedron . 2017 , 73, 1331. (IF = 2.64)
  15. A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action. Mignani, S. El Brahmi, N. El Kazzouli, S.: Eloy, L.; Courilleau, D.; Caron , J.S. Bousmina, M. Caminade, AM. Cresteil, T. Majoral, JP. Eur. J.Med. Chem . 2016 , 122, 656. (IF = 4.83)
  16. Functionalization of indazoles by means of transition metal-catalyzed cross-coupling reactions. El Kazzouli, S .; Guillaumet, G., Tetrahedron . 2016 , 72, 6711. (IF = 2.64)
  17. Synthesis and characterization of nanostructured palladium perovskites: Evaluation of their catalytic activity in cross-coupling chemistry, Essoumhi, A. Solhy, A. El Kazzouli, S. J. Mater. Approximately. Sci. 2016 , 7, 1080. (IF = 1.2)
  18. Palladium-catalyzed oxidative direct C3- and C7-alkenylations of indazoles: Application to the synthesis of Gamendazole. Naas, M. El Kazzouli, S .; Essassi, EM. Bousmina, M.; Guillaumet, G. Org. Lett . 2015 , 17, 4320. (IF = 6.55)
  19. Advances in direct CH arylation of 5,5, 6,5 and 6,6-fusedheterocycles containing heteroatoms (N, O, S). El Kazzouli, S .; Koubachi, J.; El Brahmi, N.; Guillaumet, G. RSC Advances , 2015 , 7, 3915. (IF = 3.4)
  20. Investigations in dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and corresponding monomers and dendrons with ethacrynic acid motifs. El Brahmi, N.; Mignani, S.; Caron, J.; El Kazzouli, S .; Bousmina, M.; Caminade, A-M.; Cresteil, T.; Majoral, JP. Nanoscale , 2015 , 7, 3915. (IF = 7.4)
  21. Palladium-catalyzed direct C7-arylation of substituted indazoles. Naas, M.; El Kazzouli, S .; Essassi, EM; Bousmina, M.; Guillaumet, G. J. Org. Chem . 2014 . 79, 7286. (IF = 4.80)
  22. Ceria-supported copper nanoparticles: A highly efficient and recyclable catalyst for N-arylation of indole. Amadine, O.; Maati, H.; Abdelouhadi, K.; Fihri, A.; El Kazzouli, S.; Len, C.; El Bouari, A.; Solhy. A. Journal of Molecular Catalysis A: Chemical , 2014 , 395, 409. (IF = 3.7)
  23. Functionalization of imidazo[1,2-a]pyridines by means of metal-catalyzed cross-coupling reactions – A review. Koubachi, J.; El Kazzouli, S .; Bousmina, M.; Guillaumet, G. Eur. J.Org. Chem . 2014 , 24, 5119. (IF = 3.03)
  24. Review on Palladium-containing perovskites: Synthesis, physico-chemical properties and applications in catalysis. Essoumhi, A.; El Kazzouli, S.; Bousmina, M. J. Nanosci. Nanotechnology. 2014 , 14, 2012. (IF = 1.56)
  25. Dendrimer Space Exploration: Inhibition of protein-protein interactions for the next generation of pharmaceuticals. Mignani, S.; El Kazzouli, S.; Bousmina, M.; Majoral, JP. Chem. Rev. 2014 , 114, 1327. (IF = 53)
  26. Dendrimer space concept for innovative nanomedicine: a futuristic vision in medicinal chemistry. Mignani, S.; El Kazzouli, M.; Bousmina, M.; Majoral, Progress in Polymer Science , 2013 , 38, 993. (IF = 24.50)
  27. Original multivalent copper(II)-conjugated phosphorus-dendrimers and corresponding mononuclear copper(II) complexes with anti-tumor activities. El Brahmi, N. El Kazzouli, S. Mignani, S. Essassi, E. Aubert, G. Laurent, R. Caminade, AM. Bousmina, M. Cresteil, T. Majoral, JP. Molecular Pharmaceutics , 2013 , 10, 1459. (IF = 4.4)
  28. Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview. Mignani, S.; El Kazzouli, M.; Bousmina, M.; Majoral, JP. Advanced Drug Delivery Reviews , 2013 , 65, 1316. (IF = 15.52)
  29. Copper in dendrimer's synthesis and applications of copper dendrimer systems in catalysis: a concise overview. El Brahmi N.; El Kazzouli, M.; Mignani, S.; Bousmina, M.; Majoral, JP. Tetrahedron , 2013 , 69, 3103. (IF = 2.64)
  30. Microwave-assisted Suzuki-Miyaura cross-coupling of free (NH) 3-bromoindazoles. Benyahia, A.; Naas, M.; El Brahmi, N.; El Kazzouli, S .; Essassi, EM. Majoral, JP. Guillaumet, G. Current Org. Chem. 2013 , 17, 304. (IF = 2.16)

 

 

Recent conferences

1. Plenary lecture : Copper(II)-conjugated phosphorus dendrimers: Synthesis and antitumor activities. 1st International Meeting of Molecular Chemistry, Chemiometrics and Applications (1st RICMCA), May 29-30 , 2014 at the FST in Beni Mellal, Morocco.

2. Invited lecture : Presentation of biotechnological & nantechnological applications in the pharmaceutical and Drug Design field, Biotechnology Day, March 19, 2015, CNRST, Rabat, Morocco.

3. Invited lecture : Functionalization of indazoles by direct arylation and oxidative alkenylation, June 30 , 2015 , International University Center for Research, Orleans, France.

4. Invited lecture: Synthesis of phosphorus dendrimers functionalized by copper or ethacrynic acid derivatives: Evaluation of their anticancer activities. 08 Jully 2015 , Institute of Organic and Analytical Chemistry, University of Orléans, France.

5. Invited lecture : Direct CH alrylation and alkenylation of indazoles. 11 March 2016, 5th

Spanish-Moroccan Symposium on Organic Chemistry, Casablanca, Morocco.

6. Invited lecture : Functionalization of imidazo[1,2-a]pyridine and indazole by direct arylation and oxidative alkenylation reactions, 6th International Meeting on Chemometrics, Quality and Molecular Chemistry, April 22 2016 , Beni Mellal, Morocco.

7. Oral presentation: Synthesis of new drug-phosphorus dendrimer conjugates and their evaluation as anticancer agents July 28, 2016 , Lyon, France.

8. Invited lecture: Synthesis and biological evaluation of a novel class of ethacrynic acid derivatives, International Workshop “Bioactive Molecules and Biomaterials” 03/24/2017 , FST Mohammedia, University of Casablanca.

9. Invited lecture : Functionalization of indazoles and azaindazoles by activation reactions of the CH bond, 10th edition of the Franco-Romanian Colloquium on Applied Chemistry (COFrRoCA) 26-28/06/ 2018 , Universty of Bacau , Bacau, Romania.

10. Video Conference , CH functionalization of indazoles and azaindazole, 19th Global Chemistry conferences, 20-21 March 2019 , New York, USA

11. Keynote conference, Synthesis and biological applications of dendrimers, 2th International Conference on Material Science and Material Chemistry, 20-21 March 2019, London, UK

12. Invited lecture: Design and synthesis of drug-loaded dendrimers as anticancer agents, International conference in applied and theory of nanostructures, 18-18 June 2019 , Kenitra, Morocco

 

  • General chemistry,

 

  • Organic chemistry,

 

  • Analytical Chemistry,

 

  • Synthesis, characterization and applications of organic macromolecules

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UEMF, where high-level training, cultural diversity and stimulating student life converge

Placed under the High Honorary Presidency of HIS MAJESTY KING MOHAMMED VI , the UEMF is a public utility and non-profit foundation certified by the Union for the Mediterranean (UfM) with the support of its 43 countries members. The UEMF delivers training in three cycles (Bachelor's, Engineering, Master's and Doctorate) and its diplomas are recognized by the Moroccan State and several of its training courses are in double diploma with the best Euro-Mediterranean universities.

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