EL BRAHMI Nabil

EL BRAHMI Nabil

BiomedTech engineering school

n.elbrahmi@ueuromed.org

2013 : Moroccan National Doctorate: Faculty of Sciences, Mohammed V University, Agdal, Rabat - CNRS Coordination Chemistry Laboratory, Toulouse, France).

2007 : DESA Advanced Higher Studies Diploma. (BAC+6): Faculty of Sciences, Mohammed V University, Agdal, Rabat; UFR: Pharmacochemistry.   

Organic Chemistry/Medicinal Chemistry.

2019 : Qualified Professor. Euromed University of Fez.   

2014: Assistant Professor. Euromed University of Fez.

2013 : Post-doctoral. Euromed University of Fez & Coordination Chemistry Laboratory, Toulouse, France .

2011: Research engineer. Coordination Chemistry Laboratory (CNRS, Toulouse, France)

P1) Near-infrared emitting poly(amidoamine) dendrimers with an anthraquinone core towards versatile noninvasive biological imaging.

K. Jouad, SV Eliseeva, G. Collet, C. Colas, D. Da Silva, MA. Hiebel, N. El Brahmi, M. Akssira, S. Petoud, S. El Kazzouli, F. Suzenet, Biomacromolecules, 2022, accepted (IF = 6.9).

P2) Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents.

A. El Abbouchi, N. El Brahmi, MA. Hiebel, J. Bignon, G. Guillaumet, F. Suzenet, S. El Kazzouli. Bioorg.  Chem. 2021 , 115, 105293 (IF = 5.27).  

P3) Regioselective CH Functionalization of the Six-Membered Ring of the 6,5-Fused Heterocyclic Systems: An Overview

S. Faarasse, N. El Brahmi, G. Guillaumet, S. El Kazzouli. Molecules.  2021 , 26, 5763 (IF = 4.41).

P4) A Regioselective C7 Bromination and C7 Palladium-catalyzed Suzuki–Miyaura Cross-coupling Arylation of 4-Substituted NH-free Indazoles

K. Boujdi , N. El Brahmi , J. Graton , D. Dubreuil , S. Collet , b M. Mathé-Allainmat , M. Akssira , J. Lebreton , S. El Kazzouli . RCS Advances. 2021, 11 , 7107-7114 (IF = 3.12).

P5) Design, Synthesis and Biological Evaluation of Ethacrynic Acid Derivatives Bearing Sulfonamides as Potent Anti-Cancer Agents.

A. El Abbouchi, N. El Brahmi, MA. Hiebel, J. Bignon, G. Guillaumet, F. Suzenet, S. El Kazzouli. Bioorg. Med. Chem. Lett . 2020 , 30, 127426 (IF = 2.7).

P6) Direct arylation and Suzuki-Miyaura coupling of imidazo[1,2-a]pyridines catalyzed by (SIPr)Pd(allyl)Cl complex under microwave-irradiation

A. El Abbouchi, J. Koubachi, N. El Brahmi, S. El Kazzouli. Mediterranean.  J.Chem. 2019 , 9, 347-354 (IF = 0.85).

P7) Dendrimer for Templating the Growth of Porous Catechol-Coordinated Titanium Dioxide Frameworks: Toward Hemocompatible Nanomaterials

N. Katir, N. Marcotte, S. Michlewska, M. Ionov, N. El Brahmi, M. Bousmina, JP Majoral, M. Bryszewska, A. El Kadib. ACS Applied Nano Materials . 2019, 2, 2979-2990 (5.097).

P 8) Oxidative Alkenylation of Fused Bicyclic Heterocycles

J. Koubachi , N. El Brahmi , G. Guillaumet , S. El Kazzouli . Eur. J.Org. Chem . 2019 , 15, 2568-2586 (IF = 3.03).

P9) Interfacial complexation driven three-dimensional assembly of cationic phosphorus dendrimers and graphene oxide sheets

N. Katir, A. Benayad, D. Rouchon, N. Marcotte, N. El Brahmi, JP Majoral, B. Bousmina, A. El Kadib. Nanoscale Adv . 2019 , 1, 314-321 (4.55).

P10)  Elucidating the role of surface chemistry on cationic phosphorus dendrimer-siRNA complexation

MA Deriu, N. Tsapis, M. Noiray, G. Grasso, N. El Brahmi, S. Mignani, JP Majoral, E. Fattal, A. Danani. Nanoscale . 2018 , 10, 10952-10962 (IF = 6.97).

P11)  First-​in-​Class Combination Therapy of a Copper(II) Metallo-​Phosphorus Dendrimer with Cytotoxic Agents

S. Mignani, N. El Brahmi, T. Cresteil, JP Majoral. Oncology ,  2018 , 94(5), 324-328 (IF = 2.6).

P12)  Original Multivalent Gold(III) and Dual Gold(III) - Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumor and Antimicrobial Agents

S. Mignani, N. El Brahmi, S. El Kazzouli, R. Laurent, S. Ladeira, AM Caminade, E. Pedziwiatr-Werbicka, E. Szewczyk, M. Bryszewska, M. Bousmina, T. Cresteil, JP Majoral. Mol. Pharm . 2017 , 14, 11, 4087-4097 (IF = 4.39).

P13)  Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo

I. Posadas, L. Romero-Castillo, N. El Brahmi, D. Manzanares, S. Mignani, JP Majoral, V. Cena,  PNAS USA . 2017 , 114, E7660-E7669 (IF = 11.2).

P14) Anti-Inflammatory Effect of Anti-TNF-α SiRNA Cationic Phosphorus Dendrimer Nanocomplexes Administered Intranasally in a Murine Acute Lung Injury Model

A. Bohr, N. Tsapis, I. Andreana, A. Chamarat, C. Foged, C. Delomenie, M. Noiray, N. El Brahmi, JP Majoral, S. Mignani, E. Fattal, Biomacromolecules , 2017 , 18( 8), 2379-2388 (IF = 5.67).

P15)  Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators.

S. Mignani, N. El Brahmi, L. Eloy, J. Poupon, V. Nicolas, A. Steinmetz, S. El Kazzouli, M. Bousmina, M. Blanchard-Desce, AM Caminade, JP Majoral, T. Cresteil. Eur. J.Med. Chem . 2017 , 132, 142-156 (IF = 4.83).

P16)  Symmetrical and unsymmetrical incorporation of active biological monomers on the surface of phosphorus dendrimers.

N. El Brahmi, S. El Kazzouli, S. Mignani, R. Laurent, S. Ladeira, AM Caminade, M. Bousmina, JP Majoral. Tetrahedron . 2017 , 73, 1331-1341 (IF = 2.38).

P17)  Orthogonal Synthesis of Covalent Polydendrimer Frameworks by Fusing Classical and Onion-Peel Phosphorus-Based Dendritic Units.

N. Katir, N. El Brahmi, N. Marcotte, JP Majoral, M. Bousmina, A. El Kadib. Macromolecules . 2016 , 49, 5796-5805 (IF = 5.99).

P18)  A Novel Class of Ethacrynic Acid Derivatives as Promising Druggable Potent Generation of Anticancer Agents with Established Mechanism of Action.

S. Mignani, N. El Brahmi, S. El Kazzouli, L. Eloy, D. Courillaud, J. Caron, MM Bousmina, AM Caminade, T. Cresteil, JP Majoral. Eur. J.Med. Chem. 201 6, 122, 656-673 (IF = 4.83).

P19) Synthesis, Characterization and Biological Properties of New Hybrid Carbosilane- Viologen- Phosphorus Dendrimers.

S. Moreno, A. Szwed, N. El Brahmi, K. Milowska, J. Kuroswka, E. Fuentes-Paniagua, E. Pedziwiatr-Werbicka, T. Gabryelak, N. Katir,; J. de la Mata, MA Munoz-Fernandez, R. Gomez Ramirez, AM Caminade, JP Majoral, M. Bryszewska. RCS Advances  . 2015 , 5 , 25942-25958 (IF = 3.05).

P20) Synthesis of Onion-Peel Nanodendritic Structures with Sequential Functional Phosphorus Diversity.

N. Katir, N. El Brahmi, A. EL Kadib, S. Mignani, AM Caminade, M. Bousmina, JP Majoral. Chem.  Eur. J. 2015 , 21, 1-10 (IF = 5.16).

P21)  Advances in direct C- H arylation of 5, 5- 6, 5- and 6, 6- fused- heterocycles containing heteroatoms (N, O, S).

S. El Kazzouli, J. Koubachi, N. El Brahmi, G. Guillaumet.  RCS Advances  . 2015 , 5, 15292-15327 (IF = 3.05).

P22) Investigations on dendrimer space reveal solid and liquid tumor growth- inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs.

N. El Brahmi, S. Mignani, J. Caron, S. El Kazzouli, M. Bousmina, AM Caminade, T. Cresteil, JP Majoral . Nanoscale. 2015, 7, 3915-3922 (IF = 6.97).

C1) Nabil El Brahmi, “New Copper (II) and Gold (III)-Loaded Phosphorus Dendrimers: Synthesis and Biological Evaluation” Mohammedia, Morocco September 19 and 20, 2018.

C2) Nabil El Brahmi, Metallodendrimers: Synthesis and biological applications”. International Workshop-Bio-Organic and Medicinal Chemistry -. Fez, Morocco March 22, 2017.

C3) New Drug-Loaded Phosphorus Dendrimers: Their synthesis and anticancer activities

Nabil.
El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, MM Bousmina, JP Majoral 32 nd  I nternational C onference of the P olymer Processing Society , Lyon, France 25-29 July , 2016 .

C4) Synthesis and characterization of new phosphorus-viologen-carbosilane dendrimers.

S. Moreno, Nabil El Brahmi, E. Fuentes-Paniagua, FJ de la Mata, J. P Majoral, R. Gómez.

8th International  Dendrimer Symposium , Spain 23-27 June , 2013 .

C5) Synthesis, characterization and biological evaluation of new dendrimer-copper complexes.

Nabil El Brahmi, S. El Kazzouli, R. Laurent, S. Mignani, T. Cresteil, M. Essassi, AM. Caminade, JP. Costes, M. Bousmina, JP. Majoral.

3rd  French - Moroccan Scientific Conference of the LIA . Rabat, Morocco October 15-17, 2012.

C6) Synthesis, Characterization and Biological Evaluation of New Drug-Loaded Phosphorus Dendrimers.

Nabil El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. Essassi, AM. Caminade, JP. Costes, M. Bousmina, JP. Majoral.

3rd  I nternational S ymposium on B iological A pplications of D endrimers. Toledo, Spain 5th -8th September , 2012 .

C1) Nabil El Brahmi, “New Copper (II) and Gold (III)-Loaded Phosphorus Dendrimers: Synthesis and Biological Evaluation” Mohammedia, Morocco September 19 and 20, 2018.

C2) Nabil El Brahmi, Metallodendrimers: Synthesis and biological applications”. International Workshop-Bio-Organic and Medicinal Chemistry -. Fez, Morocco March 22, 2017.

C3) New Drug-Loaded Phosphorus Dendrimers: Their synthesis and anticancer activities

Nabil.
El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, MM Bousmina, JP Majoral 32 nd  I nternational C onference of the P olymer Processing Society , Lyon, France 25-29 July , 2016 .

C4) Synthesis and characterization of new phosphorus-viologen-carbosilane dendrimers.

S. Moreno, Nabil El Brahmi, E. Fuentes-Paniagua, FJ de la Mata, J. P Majoral, R. Gómez.

8th International  Dendrimer Symposium , Spain 23-27 June , 2013 .

C5) Synthesis, characterization and biological evaluation of new dendrimer-copper complexes.

Nabil El Brahmi, S. El Kazzouli, R. Laurent, S. Mignani, T. Cresteil, M. Essassi, AM. Caminade, JP. Costes, M. Bousmina, JP. Majoral.

3rd  French - Moroccan Scientific Conference of the LIA . Rabat, Morocco October 15-17, 2012.

C6) Synthesis, Characterization and Biological Evaluation of New Drug-Loaded Phosphorus Dendrimers.

Nabil El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. Essassi, AM. Caminade, JP. Costes, M. Bousmina, JP. Majoral.

3rd  I nternational S ymposium on B iological A pplications of D endrimers. Toledo, Spain 5th -8th September , 2012 .

C1) Nabil El Brahmi, “New Copper (II) and Gold (III)-Loaded Phosphorus Dendrimers: Synthesis and Biological Evaluation” Mohammedia, Morocco September 19 and 20, 2018.

C2) Nabil El Brahmi, Metallodendrimers: Synthesis and biological applications”. International Workshop-Bio-Organic and Medicinal Chemistry -. Fez, Morocco March 22, 2017.

C3) New Drug-Loaded Phosphorus Dendrimers: Their synthesis and anticancer activities

Nabil.
El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, MM Bousmina, JP Majoral 32 nd I nternational C onference of the P olymer Processing Society , Lyon, France 25-29 July , 2016 .

C4) Synthesis and characterization of new phosphorus-viologen-carbosilane dendrimers.

S. Moreno, Nabil El Brahmi, E. Fuentes-Paniagua, FJ de la Mata, J. P Majoral, R. Gómez.

8th International Dendrimer Symposium , Spain 23-27 June , 2013 .

C5) Synthesis, characterization and biological evaluation of new dendrimer-copper complexes.

Nabil El Brahmi, S. El Kazzouli, R. Laurent, S. Mignani, T. Cresteil, M. Essassi, AM. Caminade, JP. Costes, M. Bousmina, JP. Majoral.

3rd French - Moroccan Scientific Conference of the LIA . Rabat, Morocco October 15-17, 2012.

C6) Synthesis, Characterization and Biological Evaluation of New Drug-Loaded Phosphorus Dendrimers.

Nabil El Brahmi, S. El Kazzouli, S. Mignani, T. Cresteil, M. Essassi, AM. Caminade, JP. Costes, M. Bousmina, JP. Majoral.

3rd I nternational S ymposium on B iological A pplications of D endrimers. Toledo, Spain 5th -8th September , 2012 .

  • General Chemistry/Mineral Chemistry (1st year preparatory cycle -EIBB)

 

  • Organic Chemistry I (Preparatory cycle 1st year -EIBB)

 

 

Patents

  • B1) Copolydendrimerscontainingheteroatoms M. Bousmina, N. Katir, A. El Kadib, N. El Brahmi, J.-P. Majoral, N. Marcotte. No.: WO 2017/222358 A2

 

  • B2) Antitumor study of a novel class of ethacrynic acid derivatives S. El Kazzouli, A. Zyad, N. El Brahmi, A. El Abouchi, K. Boujdi, M. Bousmina, HA Mouse, M. Tilaoui. Deposit number: 44038

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UEMF, where high-level training, cultural diversity and stimulating student life converge

Placed under the High Honorary Presidency of HIS MAJESTY KING MOHAMMED VI , the UEMF is a public utility and non-profit foundation certified by the Union for the Mediterranean (UfM) with the support of its 43 countries members. The UEMF delivers training in three cycles (Bachelor's, Engineering, Master's and Doctorate) and its diplomas are recognized by the Moroccan State and several of its training courses are in double diploma with the best Euro-Mediterranean universities.

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