Development of Next-Generation Hybrid Biomaterials Based on MOFs and Calcium Phosphates for Orthopedic Applications

The increasing demand for advanced orthopedic biomaterials that promote bone regeneration while preventing post-implantation complications has driven significant interest in multifunctional hybrid systems. Calcium phosphates, particularly hydroxyapatite and related phases, are widely recognized for their excellent biocompatibility, osteoconductivity, and chemical similarity to natural bone mineral. However, their limited antibacterial activity and lack of controlled therapeutic functionality remain major challenges in orthopedic applications.

Metal–Organic Frameworks (MOFs), a class of highly porous crystalline materials composed of metal ions and organic linkers, have recently emerged as promising candidates in biomedical fields due to their tunable porosity, high surface area, and ability to host and release bioactive molecules in a controlled manner. The integration of MOFs with calcium phosphate matrices offers a unique opportunity to design next-generation hybrid biomaterials combining structural bioactivity with multifunctional therapeutic performance.

This doctoral research aims to develop innovative hybrid biomaterials based on MOFs and calcium phosphates for orthopedic applications. The work will focus on the controlled synthesis of MOF–calcium phosphate composites, the investigation of their structural, physicochemical, and mechanical properties, and the evaluation of their biological performance. Special emphasis will be placed on improving osteointegration, enhancing antibacterial properties, and enabling the controlled release of therapeutic agents such as antibiotics, anti-inflammatory drugs, or osteogenic factors.

The thesis will also explore the interactions between the MOF component and the calcium phosphate phase at the molecular and microstructural levels, as well as the influence of composition and morphology on biodegradation and bioactivity. In vitro biological studies, including cytocompatibility, cell adhesion, proliferation, and antibacterial assays, will be conducted to assess their suitability for orthopedic use.

Overall, this research seeks to contribute to the development of smart, multifunctional biomaterials that address current limitations in bone repair and implant technology, offering promising perspectives for future orthopedic and regenerative medicine applications.

Research environment

Candidates are expected to carry out their research full-time within the structures of the Euromed University of Fes.

PhD Student’s Responsibilities

The PhD student will be expected to:

• Conduct an in-depth literature review on calcium phosphate biomaterials, metal–organic frameworks (MOFs), and hybrid systems for orthopedic applications.
• Design and develop novel MOF–calcium phosphate hybrid biomaterials using controlled synthesis routes.
• Evaluate mechanical properties relevant to orthopedic applications.
• Investigate bioactivity, biodegradation behavior, and ion/drug release profiles of the developed materials.
• Carry out in vitro biological evaluations, including cytocompatibility, cell adhesion and proliferation, and antibacterial activity tests.
• Analyze and interpret experimental data and correlate material properties with biological performance.
• Prepare scientific reports, manuscripts for publication in peer-reviewed journals, and present research results at national and international conferences.
• Ensure compliance with laboratory safety regulations and good scientific practice.

The application file must include the following documents:

• CV with photo
• A cover letter
• A copy of diplomas
• A copy of academic transcripts
• A copy of CIN/Passport

Submission of the application file

The application file must be sent to the Doctoral Studies Center (CEDoc) of the Euro-Mediterranean University of Fes by email no later than February 14, 2026, to the following email address:

Euromed-CEDoc@ueuromed.org

For more information

Administrative Affairs Officer of the CEDoc:
Ms. Boutaina Jai Mansouri – b.jai-mansouri@emadu.ueuromed.org

Director of Research and of the CEDoc:
Prof. Abdelghafour Marfak – a.marfak@ueuromed.org

Thesis supervisor

Pr. Hammouti Belkheir – hammoutib@gmail.com