El Kazzouli Saïd

Ecole d’ingénieur BiomedTech

2004: Ph.D. in Organic Chemistry

University of Orléans, Institute of Organic and Analytical Chemistry, Orléans, France. Supervisor: Professor Gérald Guillaumet, President of University of Orléans in collaboration with Professor Abderrahim Mouaddib University of Cadi Ayyad. Dissertation Title: "Solid support synthesis of various heterocycles from a common synthon. Development and pharmacological evaluation of imidazo[1,2-a]pyridine derivatives as melatonin analogues", Expertise: multi-step synthesis, imidazo[1,2- a]pyridines, melatonin analogues, palladium and copper–catalyzed reactions, solid support synthesis, microwave synthesis.

2000: M.S. in Organic Chemistry

Universities of Orléans, Paris V and Paris XI

Thesis Title: "Support solid synthesis of large C-terminal peptide aldehyde: application to chemoselective ligation". Expertise: solid phase synthesis, peptide chemistry. Centre National de la Recherche Scientifique (CNRS), Centre de Biophysique Moléculaire, Orléans, France. Supervisor: Agnès Delmas, Ph.D.

1997: B.S. in Chemistry, Faculté des Sciences et Techniques (FST), Beni-Mellal, Morocco.


  • Chimie médicinale
  • Méthodologies de synthèse, 
  • Chimie verte, 
  • Macromolécules pour la vectorisation des principes actifs (dendrimères)

2013-Present:    Euro-Mediterranean University of Fes (UEMF), Morocco. Design and synthesis of   bioactive molecules, drugs delivery by macromolecules, environmental chemistry, green chemistry, phosphate forth flotation and catalysis.

2009-2013:   Institute of  Nanomaterials and  Nanotechnology, Moroccan  Foundation for Advanced Sciences, Innovations and Research (MAScIR), Rabat, Morocco. Design and synthesis of bioactive molecules, drugs delivery by dendrimers, phosphate forth flotation, homogenous catalysis.

2006-2009:  National Institutes of Health (NIH), National Cancer Institute (NCI), Frederick, Maryland, Centre for Cancer Research, Laboratory of Medicinal Chemistry, USA. 

Postdoctoral Fellow (IRTA Fellow): Rational drug design and multi-step synthesis of antitumor agents, purification and characterization of biologically active diacylglycerol-lactones (DAG-lactones). Expertise: solid phase synthesis, parallel synthesis, combinatorial chemistry, diacylglycerol-lactones (DAG-lactones), protein kinase C (PKC), C1-domains.

2004-2006: University of Orléans, Institute of Organic and Analytical Chemistry, Orléans, France.

2005-2006: Postdoctoral Fellow in Heterocyclic Chemistry: Synthesis of herbicide, Expertise: indole chemistry, anionic reactions, in collaboration with Syngenta, Basel, Switzerland.

2005: Postdoctoral Fellow in Nucleosides Chemistry: Synthesis of new antiviral drugs, Expertise: nucleosides chemistry, palladium–catalyzed reactions, solid support synthesis, microwave synthesis. France

2004:  Postdoctoral  Fellow in Heterocyclic Chemistry: Synthesis of new pyrimido[4,5-b][1,4]oxazines, Expertise: pyrimido[4,5-b][1,4]oxazines, palladium-catalyzed N- arylation, microwave synthesis. France



  1. Design, synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents, El Abbouchi, A.; El Brahmi, N.; Hiebel, M-A.; Bignon, J.; Guillaumet, G.; Suzenet, F.; El Kazzouli, S. Bioorg. Med. Chem. Lett. 2020, Accepted. (IF = 2.42).
  2. Palladium-catalyzed oxidative arylation of 1H-indazoles with arenes. Gambouz, K.; El Abbouchi, A.; Nassiri, S., Bousmina, M.; Akssira, M.; Guillaumet, G.; El Kazzouli, S. Eur. J. Org. Chem. 2020, Accepted. (IF = 3.03).
  3. “On Water” Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole, Gambouz, K.; El Abbouchi, A.; Nassiri, S., Bousmina, M.; Akssira, M.; Guillaumet, G.; El Kazzouli, S. Molecules. 2020, 25, 1645. (IF = 3.06).
  4. Direct arylation and Suzuki-Miyaura coupling of imidazo[1,2-a]pyridines catalyzed by (SIPr)Pd(allyl)Cl complex under microwave-irradiation. El Abbouchi, A.; Koubachi, J.; El Brahmi, N.; El Kazzouli. S. Med J. Chem. 2019, 9, 347. (IF = 0.85).
  5. Unusual rearrangement of imidazo[1,5-a]imidazoles and imidazo[1,2-b]pyrazoles into imidazo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines, Gambouz, K.; Loubidi, M.; Tber, Z.; Driowy, M.; Allouchi, H.; El Kazzouli, S. Akssira, M.; Guillaumet, G. RSC Advances, 2019, 9, 29051. (IF = 3.05).
  6. Oxidative alkenylation of fused bicyclic heterocycles. Koubachi, J.; El Brahmi, N.; Guillaumet, G.; El Kazzouli, S. Eur. J. Org. Chem. 2019, 2568. (IF = 3.03).
  7. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1). Mignani, S.; Rodrigues, J.; Roy, R.; Shi, X.; Cenã, V.; El Kazzouli, S.; Majoral. J-P. Drug Discov. Today, 2019, 24, 1176. (IF = 6.88).
  8. Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 2). Mignani, S.; Rodrigues, J.; Roy, R.; Shi, X.; Cenã, V.; El Kazzouli, S.; Majoral. J-P. Drug Discov. Today, 2019, 24, 1184. (IF = 6.88).
  9. Palladium-catalyzed C3 arylations of 1H and 2H pyrazolo[4,3-b]pyridines on water: One pot direct C3-arylations of 1H and 2H series. Faarasse, S.; El Kazzouli, S.; Suzenet, F.; Guillaumet, G., J. Org. Chem. 2018, 83, 12847-12854 (IF = 4.80).
  10. Synthesis and characterization of new organophilic clay. Preparation of polystyrene/clay nanocomposite, Ben-Yahia, A.; El Kazzouli, S.; Essassi, E.M.; Bousmina, M.M. Scientific Study and Research: Chemistry and Chemical Engineering, Biotechnology, Food Industry, 2018, 19, 193. (IF = 0.23)
  11.  “On water” direct C-3 arylation of 2H-pyrazolo[3,4-b]pyridines, Faarasse, S. El Kazzouli, S.; Naas, M.; Jouha, J.; Suzenet, F.; Guillaumet, G., J. Org. Chem. 2017, 82, 12300. (IF = 4.80)
  12. Original Multivalent Gold(III) and Dual Gold(III)–Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents, Mignani, S.; El Brahmi, N.; El Kazzouli, S.; Laurent, R.; Ladeira, S.; Caminade, A-M.; Pedziwiatr-Werbicka, E.; Szewczyk, E. M.; Bryszewska, M.; Bousmina, M.; Cresteil, T.; Majoral, J-P. Molecular Pharmaceutics. 2017, 14, 4087. (IF = 4.40)
  13. Anticancer copper(II) phosphorus dendrimers are potent proapoptotic Bax activators. Mignani, S. El Brahmi, N.; Eloy, L.; Poupon, J.; Nicolas, V.; Steinmetz, A.; El Kazzouli, S.; Bousmina, M. ; Blanchard-Desce, M.; Caminade, A-M.; Majoral, J-P.; Cresteil, T. Eur. J. Med. Chem. 2017, 132, 142. (IF = 4.83)
  14. Symmetrical and unsymmetrical incorporation of active biological monomers on the surface of phosphorus dendrimers. El Brahmi, N.; El Kazzouli, S.; Mignani, S.; Laurent. R.; Ladeira. S.; Caminade, A-M.; Bousmina, M.; Majoral, J-P. Tetrahedron. 2017, 73, 1331. (IF = 2.64)
  15. A  novel  class  of  ethacrynic  acid  derivatives  as  promising  drug-like  potent  generation  of anticancer agents with established mechanism of action. Mignani, S. El Brahmi, N. El Kazzouli, S.: Eloy, L.; Courilleau, D.; Caron, J. S. Bousmina, M. Caminade, A-M. Cresteil, T. Majoral, J-P. Eur. J. Med. Chem. 2016, 122, 656. (IF = 4.83)
  16. Functionalization  of  indazoles  by  means  of  transition  metal-catalyzed  cross-coupling reactions. El Kazzouli, S.; Guillaumet, G., Tetrahedron. 2016, 72, 6711. (IF = 2.64)
  17. Synthesis and  characterization  of  nanostructured  palladium  perovskites:  Evaluation  otheir catalytic activity in cross-coupling chemistry, Essoumhi, A. Solhy, A. El Kazzouli, S. J. Mater. Environ. Sci. 2016, 7, 1080. (IF = 1.2)
  18. Palladium-catalyzed oxidative direct C3- and C7-alkenylations of indazoles: Application to the synthesis of Gamendazole. Naas, M. El Kazzouli, S.; Essassi, EM. Bousmina, M.; Guillaumet, G. Org. Lett. 2015, 17, 4320. (IF = 6.55)
  19. Advances in direct C-H arylation of 5,5, 6,5 and 6,6- fusedheterocycles containing heteroatoms (N, O, S). El Kazzouli, S.; Koubachi, J.; El Brahmi, N.; Guillaumet, G. RSC Advances, 2015, 7, 3915. (IF = 3.4)
  20. Investigations in dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and corresponding monomers and dendrons with ethacrynic acid motifs. El Brahmi, N.; Mignani, S.; Caron, J.; El Kazzouli, S.; Bousmina, M.; Caminade, A- M.; Cresteil, T.;  Majoral, J-P. Nanoscale, 2015, 7, 3915. (IF = 7.4)
  21. Palladium-catalyzed direct C7-arylation of substituted indazoles. Naas, M.; El Kazzouli, S.; Essassi, E. M.; Bousmina, M.; Guillaumet, G. J. Org. Chem. 2014. 79, 7286. (IF = 4.80)
  22. Ceria-supported copper nanoparticles: A highly efficient and recyclable catalyst for N-arylation of indole. Amadine, O.; Maati, H.; Abdelouhadi, K.; Fihri, A.; El Kazzouli, S.; Len, C.; El Bouari, A.; Solhy. A. Journal of Molecular Catalysis A: Chemical, 2014, 395, 409. (IF = 3.7)
  23. Functionalization of imidazo[1,2-a]pyridines by means of metal-catalyzed cross-coupling reactions – A review. Koubachi, J.; El Kazzouli, S.; Bousmina, M.; Guillaumet, G. Eur. J. Org. Chem. 2014, 24, 5119. (IF = 3.03)
  24. Review  on  Palladium-containing  perovskites:  Synthesis,  physico-chemical  properties  and applications  icatalysis.  EssoumhiA.;  El  Kazzouli,  S.;  Bousmina,  M.  J.  Nanosci. Nanotechnol. 2014, 14, 2012. (IF = 1.56)
  25. Dendrimer Space Exploration: Inhibition of protein-protein interactions for the next generation of pharmaceuticals. Mignani, S.; El Kazzouli, S.; Bousmina, M.; Majoral, J-P. Chem. Rev. 2014, 114, 1327. (IF = 53)
  26. Dendrimer space concept for innovative nanomedicine: a futuristic vision in medicinal chemistry.  Mignani,  S.;  El  KazzouliM.;  Bousmina,  M.;  Majoral,  Progress  in  Polymer Science, 2013, 38, 993. (IF = 24.50)
  27. Original  multivalent  copper(II)-conjugated  phosphorus-dendrimers  and  corresponding mononuclear copper(II) complexes with anti-tumoral activities. El Brahmi, N. El Kazzouli, S. Mignani, S. Essassi, E. Aubert, G. Laurent, R. Caminade, A-M. Bousmina, M. Cresteil, T. Majoral, J-P. Molecular Pharmaceutics, 2013, 10, 1459. (IF = 4.4)
  28. Expand classical drug administration ways by emerging routes using dendrimer drug delivery systems: a concise overview. Mignani, S.; El Kazzouli, M.; Bousmina, M.; Majoral, J-P. Advanced Drug Delivery Reviews, 2013, 65, 1316. (IF = 15.52)
  29. Copper in dendrimer’s synthesis and applications of copper dendrimer systems in catalysis: a concise overview. El Brahmi N.; El Kazzouli, M.; Mignani, S.; Bousmina, M.; Majoral, J-P. Tetrahedron, 2013, 69, 3103. (IF = 2.64)
  30. Microwave-assisted Suzuki-Miyaura cross-coupling of free (NH) 3-bromoindazoles. Benyahia, A.; Naas, M.; El Brahmi, N.; El Kazzouli, S.; Essassi, EM. Majoral, J-P. Guillaumet, G. Current Org. Chem. 2013, 17, 304. (IF = 2.16)


Book Chapters


  1. 1,4-Dioxins, oxathiins, dithiins and their benzo derivatives, Book chapter 8.2, Comprehensive heterocyclic Chemistry IV, Elsevier. Tikad, A.; El Kazzouli. S.; Guillaumet, G. 2020, Accepted.
  2. Recent Advances in Oxidative Alkenylation of five and six-membered heterocyclic ring systems, Targets in Heterocyclic Systems - Chemistry and Properties, Italian Society of Chemistry. El Brahmi, N.; Koubachi, J.; Guillaumet, G.; El Kazzouli. S. 2020, submitted.




1.    Activités antitumorales d’une nouvelle famille de dérivés de l’acide ethacrynique, N° de dépôt: 44038, 29/11/2018. Submitted to PCT, Int. Appl. In 2019. El Kazzouli S.; Abdelmajid, Z.; El Brahmi N.; El Abbouchi A.; Boujdi K.; Bousmina M.; Ait Mouse H.; Tilaoui M.


Recent conferences


1.  Plenary lecture: Copper(II)-conjugated phosphorus dendrimers: Synthesis and antitumoral activities.1ère Rencontre Internationale de Chimie Moléculaire, Chemiométrie et Applications (re RICMCA), 29-30 Mai 2014 à la FST de Beni Mellal, Morocco.

2.     Invited lecture: Présentation des applications biotechnologiques & nantechnologiques dans le domaine pharmaceutique et Drug Design, Journée de la Biotechnologie, 19 March 2015, CNRST, Rabat, Morocco.

3.     Invited lecture: Functionalisation of indazoles by direct arylation and oxydative alkenylation, 30 June 2015, Centre international universitaire pour la recherche, Orleans, France.

4.     Invited lecture: Synthesis of phosphorus dendrimers functionalized by copper or ethacrynic acid derivatives: Evaluation of their anticancer activities. 08 Jully 2015, Institut de Chimie Organique et Analytique, University of Orléans, France.

5.     Invited lecture: Direct  C-H  alrylation  and  alkenylation  of  indazoles.  11 March 2016,  5th

Spanish-Moroccan Symposium on Organic Chemistry, Casablanca, Morocco.

6.     Invited lecture: Fonctionnalisation de limidazo[1,2-a]pyridine et de l’indazole par des réactions darylation directe et dalcénylation oxydative, 6ème Rencontre Internationale sur la Chimiométrie, la Qualité et la Chimie Moléculaire, 22 April 2016, Beni Mellal, Morocco.

7.     Oral presentation: Synthesis of new drug-phosphorus dendrimer conjugates and their evaluation as anticancer agents 28 July 2016, Lyon, France.

8.       Invited lecture: Synthesis and biological evaluation of a novel class of ethacrynic acid derivatives, Workshop International “Molécules Bioactives et Biomatériaux” 24/03/2017, FST Mohammedia, University of Casablanca.

9.       Invited lecture : Fonctionnalisation des indazoles et azaindazoles par des réactions d’activation de la liaison C-H, 10ème édition du Colloque Franco-Roumain de Chimie Appliquée (COFrRoCA) 26-28/06/2018, Universty of Bacau, Bacau, Romania.

10.     Video Conference, C-H functionalization of indazoles and azaindazole, 19th Global Chemistry conferences, 20-21 March 2019, New York, USA

11.     Keynote conference, Synthesis and biological applications of dendrimers, 2th International Conference on Material Science and Material Chemistry, 20-21 March 2019, London, UK

12.     Invited lecture: Design and synthesis of drug-loaded dendrimers as anticancer agents, International conference in applied and theory of nanostructures, 18-18 June 2019, Kenitra, Morocco

  • Chimie génerale
  • Chime organique
  • Chimie analytique
  • Synthèse, caractérisation et applications des macromolécules organiques